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Revolution Plus Topical Solution for Cats, 5.6-11 lbs, (Orange Box)


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  • Item Number: 158994
  • For Use: Cats
  • Common Brand Name(s): Revolution Plus, Paradyne
  • Generic Name: Selamectin
  • Administration Form: Topical
  • Kills or Treats: Fleas, Ticks, Ear Mites, Roundworms, Hookworms
  • Repels or Prevents: Fleas, Heartworms
  • Lifestage: All Lifestages, Adult
  • Breed Size: Medium Breeds
  • Product Form: Solution
  • Strength: 30 mg Selamectin and 5 mg Sarolaner
  • Health Condition: Ear Mites, Roundworms, Heartworms, Fleas, Ticks, Hookworms
  • Drug Type: Parasiticide


30 mg Selamectin and 5 mg Sarolaner.


Storage Instructions

Store at temperatures between 59-86°F.




Revolution Plus for Cats prevents Dirofilaria immitis-related heartworm disease. It controls and treats Ancylostoma tubaeforme (intestinal hookworms), and controls and treats Toxocara cati (intestinal roundworms). Controls and treats Otodectes cynotis (ear mite) infestations. Controls and treats Dermacentor variabilis (American dog tick), Amblyomma maculatum (Gulf Coast tick), and Ixodes scapularis (black-legged tick) infestations. Prevents and treats flea infestations. Kills adult Ctenocephalides felis (fleas). Works for a full month to protect kittens and cats.

Key Benefits:

  • Revolution Plus combines Sarolaner with Selamectin.
  • Sarolaner is an insecticide and acaricide that blocks glutamate-gated and GABA chloride channels in the acarine and insect nervous system.
  • This causes increased stimulation of the nerves, then parasite death.
  • Selamectin works to paralyze and/or kill a broad range of parasites (invertebrates) by interfering with the conductance of their chloride channels.
  • This disrupts normal transmission, inhibiting nerve cell electrical activity of nematodes and muscle cells of arthropods.
  • This causes paralysis and/or death of the parasite.

    Formulated For: For cats and kittens 8 weeks or older and weigh 2.8 lbs or more.

    How is Medication Given? Use as directed by your Veterinarian.

    What Results Can I Expect? Features of Revolution Plus for Cats:

  • Each application protects for 1 month.
  • Spot-on, topical treatment is easy to apply.
  • Offers 6-in-1 protection against hookworms, roundworms, ear mites, ticks, and fleas

    What Form Does Medication Come In? Spot-On

    Dose and Administration: Sold as a 3-month or 6-month supply in three different weight-based strengths.

    Possible Side Effects: Potential adverse reactions include:

  • Lesions at the administration site
  • Hair changes at the administration site
  • Sneezing
  • Conjunctivitis
  • Pruritus
  • Anorexia
  • Skin lesions
  • Eczema
  • Emesis
  • Diarrhea
  • Lethargy
    Revolution contains Sarolaner, an isoxazoline drug. This drug class is associated with certain neurological effects, including:
  • Seizures
  • Ataxia
  • Tremors
    These effects are possible whether or not the cat has a history of a neurological condition. Administer cautiously to a cat with a known neurological disorder.

    Precautions: This product is flammable and should be kept away from ignition sources, open flame, sparks, or heat. Administer cautiously and use soap and water to wash your hands following application. This product can irritate the eyes and skin. Safety is not proven for use in lactating, pregnant, or breeding cats, or in kittens under 8 weeks old. Keep out of reach of animals and children.

    Storage Recommendations: Store in a cool and dry location between 59- 86 degrees F (15-30 degrees C).

    In case of Overdose: Call your nearest emergency pet hospital.


Firmly press the cap down to puncture the seal on the Revolution Plus tube: a clicking sound will confirm that the cap has successfully punctured the seal. Remove the cap and check to ensure that the tip of the tube is open. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin in visible. Place the tip of the tube on the skin and squeeze the tube 3-4 times to empty its entire contents directly on to the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Check the tube to ensure that it is empty. Do not massage the product into the skin. Due to the alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the coat is wet. Stiff hair, clumping of hair, hair discoloration, or a slightly powdery residue may be observed at the treatment site in some cats.


The safe use of Revolution Plus has not been established in kittens less than 8 weeks old or in breeding, pregnant or lactating cats.


Your pet must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Heartworm testing is performed annually by your veterinarian to help protect your furry friend.

What is Revolution Plus?
This once-a-month topical (on-the-skin) treatment is truly a revolutionary idea in parasite protection. In Cats, Revolution Plus protects against heartworm, roundworms, hookworms, fleas, ticks and even ear mites when used as directed.

Who is it for?
For cats/kittens over 8 weeks of age and weighing 2.8 pounds or greater.

What are the benefits?

  • Heartworm-preventive cats and kittens
  • medication also can be used to treat and control roundworms and hookworms in cats
  • Also delivers flea & tick control and prevention

How does Revolution Plus work?
Revolution Plus is used in the prevention, control, and treatment of various parasite infections. The active ingredients are sarolander and selamectin, which interferes with the parasite’s nervous system. It is an effective heartworm preventive, killing the immature form of the heartworm (Dirofilaria immitis). It kills adult fleas (Ctenocephalides felis) and prevents flea eggs from hatching for one month. It is also used for the treatment and control of ear mites (Otodectes cynotis) Revolution Plus is effective in controlling tick infestations. Revolution Plus also treats and controls roundworm and hookworm infections.

How is it given?
For the prevention of heartworm disease, Revolution Plus must be applied monthly, preferably on the same date each month. It is recommended that Revolution Plus be used year-round, although some veterinarians may recommend using it only during the mosquito season. If used seasonally, the first dose must be applied within 30 days of the pet’s first exposure to mosquitoes. The last dose must be applied within 30 days after the pet’s last exposure to mosquitoes.

To control fleas, apply the first dose one month prior to the expected start of the flea season.

Part the hair on the back of the pet at the base of the neck in front of the shoulder blades. Place the tip of the tube on the skin and squeeze the tube 3-4 times to empty the entire contents on the skin. Do not massage into skin or apply to broken skin. Do not apply when the haircoat is wet.

What results can I expect?
Revolution Plus will kill the immature heartworms the pet was exposed to in the preceding month. For ear mites, most mites are killed with one treatment, although a second treatment a month later may be required; follow the advice of your veterinarian. To control ticks, the dosage may need to be changed from the heartworm dose of once a month; again follow your veterinarian’s recommendations. Most fleas are killed within 36 hours of application. If the pet was already infested with fleas when Revolution Plus was applied, you may see fleas after that period as the immature forms of the fleas in the environment hatch.

What form(s) does it come in?

Brand Name
Revolution Plus

REV-o-LOO-shun Plus

Common Drug Name
Selamectin and Sarolaner

What should I discuss with my veterinarian while considering Revolution Plus?
Talk to your veterinarian about the heartworm testing that is recommended before starting your pet on a heartworm prevention program.

Some intestinal parasites, such as hookworms and roundworms can be spread to people. Talk to your veterinarian about other measures you can take to prevent your pet from being infected with intestinal worms, and protecting yourself.

Notify your veterinarian of any other medications or supplements your pet is taking, and also if your pet has had any reactions to previous medications.

What should I do if I miss a dose?
If a dose is missed and over 30 days have gone by since the last dose, apply Revolution Plus immediately and resume a monthly dosing schedule. Tell your veterinarian that a dose was missed.

What is the most important information I should know?
If the interval between doses is longer than one month, the efficacy of the drug is reduced. Do not give this medication orally.

Who should not take it?
The safe use of Revolution Plus has not been established in kittens less than 8 weeks old or in breeding, pregnant or lactating cats. Use with caution in cats with a history of neurological disorders.

This medication should only be given to the pet for which it was prescribed.

What side effects may be seen when taking Revolution Plus?
Side effects are very rare, but may include lethargy and anorexia. If Revolution Plus is accidently given orally, you may see drooling and vomiting. Contact your veterinarian immediately if you observe any of these signs. Sarolaner, one of the ingredients in Revolution Plus, is a member of the isoxazoline class, which has been associated with adverse reactions such as tremors, ataxia and seizures. Reactions occurred in cats with or without a history of neurological disorders.

How is it stored?
Store below 86°F. Keep out of reach of children and pets.

What should I do if I know of or suspect there has been an overdose?
If you know or suspect your pet has had an overdose, or if you observe weakness, staggering, dilated pupils, trembling, drooling, or pressing the head against a wall, contact your veterinarian immediately.

What should I avoid when giving my pet Revolution Plus?
Although there are no known drug or food interactions with this medication, consult with your veterinarian before using Revolution Plus with any other medications, including vitamins and supplements, since interactions may occur.

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