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Centragard Topical Solution for Cats, 5.6-16.5 lbs, (Red Box)


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  • Item Number: 153931
  • For Use: Cats
  • Common Brand Name(s): Centragard
  • Generic Name: Praziquantel
  • Administration Form: Topical
  • Repels or Prevents: N/A
  • Kills or Treats: Roundworms, Hookworms, Heartworms
  • Lifestage: All Lifestages, Adult
  • Breed Size: Large Breeds
  • Product Form: Solution
  • Strength: 3.6 mg Eprinomectin and 74.7 mg Praziquantel
  • Health Condition: Heartworms
  • Drug Type: Parasiticide


74.7 mg Praziquantel, 3.6 mg Eprinomectin.


Storage Instructions

Store at or below 86°F (30°C) with excursions permitted to 104°f (40°c). Protect from light.


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Centragard for Cats is a topical, spot-on, once-monthly treatment that prevents heartworm disease associated with Dirofilaria immitis, controls and treats roundworms (adult and fourth stage larvae of Toxocara cati), controls hookworms (adult and fourth stage larvae of Ancylostoma tubaeforme and adult Ancylostoma braziliense), and controls tapeworms (adult Dipylidium caninum and Echinococcus multilocularis).

Key Benefits:

  • The nerve and muscle cells of invertebrates are known to contain glutamate-gated chloride channels.
  • Eprinomectin binds to these channels.
  • It works to increase the permeability of the cell membrane to those chloride ions, which triggers nerve or muscle cells hyperpolarization, then paralysis of the parasite, and finally, death of the parasite.
  • Although Praziquantel has an unknown mode of action, tapeworms exposed to this medication are known to become paralyzed, then experience rapid tegument disruption and influx of calcium ion.Formulated For: For kittens and cats aged 8 weeks and older and weigh more than 1.8 lbs.

    How is Medication Given? Recommended Dosage Rate:

  • Cats 1.8 to 5.5 Pounds: 0.3 mL Dose (24.9 mg Praziquantel and 1.2 mg Eprinomectin)
  • Cats 5.6 to 16.5 Pounds: 0.9 mL Dose (74.7 mg Praziquantel and 3.6 mg Eprinomectin)
  • Cats 16.6 to 22 Pounds: 0.3 mL + 0.9 mL Doses (99.6 mg Praziquantel and 4.8 mg Eprinomectin)
  • Cats 22.1 to 33 Pounds: 0.9 mL + 0.9 mL Doses (149.4 mg Praziquantel and 7.2 mg Eprinomectin)
  • Minimum recommended dosage rate is 0.055 mL per pound of body weight, which provides 4.55 mg of Praziquantel and 0.23 mg of Eprinomectin for every pound of body weight.
  • Full applicator contents should be topically applied monthly.
  • To use, pull the applicator plunger back slightly, then remove its cap.
  • Part the hair in a single place on the neck’s midline (between the shoulder blades and skull base).
  • Place the applicator tip against the skin, then apply contents onto the skin.
  • If your cat needs another application (based on weight), use the same method and apply in the same place.
  • Dispose of applicator.What Results Can I Expect: Centragard for Cats:
  • Prevents heartworm disease
  • Treats and controls roundworms
  • Treats and controls hookworms
  • Treats and controls tapeworms
  • Easy to apply
  • Spot-on topical formula
  • Administered monthlyWhat Form Does Medication Come In? Liquid, Spot-On

    Dose and Administration: Sold in a 3-month or 6-month, weight-based supply as follows:

  • Cats 1.8 to 5.5 Pounds: 0.3 mL Dose (24.9 mg Praziquantel and 1.2 mg Eprinomectin)
  • Cats 5.6 to 16.5 Pounds: 0.9 mL Dose (74.7 mg Praziquantel and 3.6 mg Eprinomectin)Possible Side Effects:
  • Proper application can mitigate the risk of side effects.
  • Safety studies demonstrated that some cats had transient neurological signs, including ataxia, disorientation, lethargy, or pupil dilation.
  • Oral Centragard ingestion may cause hypersalivation, vomiting, and/or lethargy.
  • In clinical trials, cats who licked their application sites after treatment experienced transient excessive salivation.
  • After treatment, rare reactions have occurred at the application site. Such mild, transient reactions include coat clumping, coat spiking, itching, or hair loss.Precautions:
  • Keep away from children and animals.
  • Not for human use.
  • Never allow contact with the application site for 5 hours post-treatment.
  • Wash hands thoroughly after handling.
  • If eye contact occurs, flush the affected eye(s) with copious amounts of water.
  • In case of accidental ingestion, skin irritation, or eye irritation, consult poison control or your veterinarian for treatment advice.
  • If this product is accidentally orally administered or ingested through application site licking or grooming, cats may experience excessive salivation or vomiting. Not intended for oral administration.
  • Not proven safe for use in breeding, pregnant, or lactating cats, in kittens weighing less than 1.8 pounds, or in kittens under 7 to 9 weeks of age.

Storage Recommendations: Store in a dry and cool environment 59- 86 degrees F (15-30 degrees C). with brief excursions permitted to 104 degrees F (40 degrees C). Shield from light.

In Case of Overdose: Contact the nearest emergency pet clinic.


What parasites does Centragard protect against?

Centragard is also approved to treat and control three of the most common intestinal parasites of cats — hookworms, roundworms, and tapeworms. It is the first, and only, product to protect against this spectrum of parasites in an easy-to-use transdermal formulation.

My cat only lives indoors. Is parasite protection necessary?

Even indoor cats are at risk of exposure to these parasites. According to the American Heartworm Society, 1 in 4 cats diagnosed with heartworm disease are indoor-only pets.

What is Heartworm Disease?

Heartworm disease is a serious and potentially fatal disease that can affect dogs, cats, and other animals. The risk of heartworms is widespread in the U.S. Heartworms are transmitted by infected mosquitoes. Mosquitoes become infected with heartworm microfilariae while taking a blood meal from an infected dog, and then can transmit the heartworms to cats. Once in the cat, heartworm larvae develop in the cat’s tissues and then migrate to the bloodstream. They reach the blood vessels of the heart and lungs in a few months.

What is the best number to call regarding any specific product questions?

For any specific product questions, please call Boehringer Ingelheim Animal Health’s customer service line number at 1-888-637-4251.

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